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In this manner, CSB resembles impulse control disorders such as kleptomania, pathological gambling, and eating disorders such as bulimia nervosa and binge eating disorder. Although there have been no brain imaging studies of CSB, it has been suggested that damage to the frontal lobes can result in disinhibition of sexual behavior, and thus, hypersexual, or CSB Coleman, DTI has been used to provide quantitative information about white matter organization and integrity.
The DTI data can be represented in a number of ways, including fractional anisotropy FAa measure of the extent to which water diffusion is directionally restricted, and mean diffusivity MDa measure of overall diffusivity in the tissue. These investigators found that FA was significantly lower in the inferior frontal regions of individuals with kleptomania, indicating altered white matter organization in this region of the brain, which influences executive function and inhibitory control Hoptman, et al.
Given the results for kleptomania and the presence of impulsivity in CSB, we hypothesized that we would find greater disorganization of white matter on DTI in the frontal lobes of men with CSB and that this white matter disorganization would be associated with greater impulsivity in CSB patients than non-CSB controls. Subjects Eight men who met the proposed research criteria for CSB described above were recruited from a treatment program for individuals seeking treatment for sexual problems.
One subject had a history of obssessive-compulsive disorder and another one subject reported current social phobia. Eight male age-matched controls were selected from a database of healthy individuals who were willing to participate in imaging research studies.
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The mean ages of the CSB and control groups were Subjects ranged in age from 19 to 51 years and were not significantly different. All of the CSB participants were Caucasian and all but one of the control participants were Caucasian. Neither the educational level or employment level variables were significantly different. Procedures All participants were screened to determine if they were eligible for and interested in participating in the study.
Subsequently an initial evaluation was scheduled. These interviews were used to determine if the participant met criteria for CSB and had no active major psychiatric illnesses or substance use disorder as these were conditions that would preclude participation in the study. During the initial appointment participants also completed several self-rating scales including: If you post personally identifiable information on the Site, such as in comments to a story, in a forum on the Site, in a blog or in an advertisement, then we may collect that information as well.
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